Advances in Brief Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg 1 DNA Glycosylases

@inproceedings{Russo2004AdvancesIB,
  title={Advances in Brief Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg 1 DNA Glycosylases},
  author={Mar{\'i}a Teresa Russo and Gabriele De Luca and Paolo Degan and Eleonora Parlanti and Eugenia Dogliotti and Deborah E. Barnes and T. Lindahl and Hanjing Yang and J. H. Miller and Margherita Bignami},
  year={2004}
}
The OGG1 and MYH DNA glycosylases prevent the accumulation of DNA 8-hydroxyguanine. In Myh / mice, there was no time-dependent accumulation of DNA 8-hydroxyguanine in brain, small intestine, lung, spleen, or kidney. Liver was an exception to this general pattern. Inactivation of both MYH and OGG1 caused an age-associated accumulation of DNA 8-hydroxyguanine in lung and small intestine. The effects of abrogated OGG1 and MYH on hepatic DNA 8-hydroxyguanine levels were additive. Because there is… CONTINUE READING

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