• Corpus ID: 49568265

Advances in Allergy Testing : Component Resolved Diagnostics

  title={Advances in Allergy Testing : Component Resolved Diagnostics},
Immunoglobulin E (IgE)-mediated allergic conditions are increasing worldwide. They affect the quality of life of millions of individuals, causing enormous costs for society. Traditionally the diagnosis of allergic disease is based on a careful and thorough clinical history, skin prick testing, laboratory testing for allergen-specific IgE (sIgE) and elimination-provocation diets. Since the discovery of the IgE antibody in 1967, considerable advances have been made in the development of in vitro… 


Molecular diagnosis in allergy
  • J. Sastre
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2010
This review provides a brief overview of basic information on allergen components, recombinants or purified, currently available or soon to become commercially available in ImmunoCAP or ISAC® systems, including names, protein family and function.
Molecular allergology approach to allergic diseases in the paediatric age
IgE sensitization to major genuine allergens and panallergens will be presented andcule-based diagnostic tools can lead to better interpretation of poly-sensitizations, observed by ST and in vitro tests using allergenic extracts as they were made before.
Diagnostic problems due to cross‐reactions in food allergy
The immunochemical cross-reactivity of allergens is a common problem of diagnostic procedures, especially in food allergy (1). Cross-reactivity can elicit positive in vitro or in vivo allergy tests
Component-Resolved Diagnosis in Pediatrics
It may be appropriate to determine IgE antibodies to components as part of the diagnostic work-up in selected cases of peanut and birch pollen allergy and in hymenoptera allergy, but cost benefit analyses of component resolved diagnosis compared with traditional work- up of allergy are needed.
Microarray based IgE detection in poly-sensitized allergic patients with suspected food allergy - an approach in four clinical cases.
The possibility to carry out multiple sIgE measurements with single protein allergens, in particular with the microarray technique, is a useful, simple and non-invasive diagnostic tool in complex poly-sensitized allergic patients.
Protein microarrays in diagnosing IgE-mediated diseases: spotting allergy at the molecular level
The development of novel protein microarray-based allergy diagnostic tests is portrayed in concert with the recent advances and benefits of this technology, along with the challenges that must be met by manufacturers in order to succeed with innovative allergen microarrays in a highly competitive market.
Allergy testing in children: why, who, when and how?
To establish evidence-based recommendations on allergy testing in children, a well-organised cooperation between primary care physicians for children and specialists in allergy is crucial in order to ensure a high quality and effectiveness of allergy diagnosis and treatment to the benefit of the individual patient.
Panallergens and their impact on the allergic patient
The panallergen concept encompasses families of related proteins, which are involved in general vital processes and thus, widely distributed throughout nature. Plant panallergens share highly
Sequence homology: A poor predictive value for profilins cross-reactivity
Comparison of three-dimensional models of watermelon and melon profilin indicated amino acid differences influence the electric potential and accessibility of the solvent-accessible surface of profilins that may markedly affect conformational epitopes.