Advances and controversies in the diagnosis and management of medullary thyroid carcinoma.

@article{Heshmati1997AdvancesAC,
  title={Advances and controversies in the diagnosis and management of medullary thyroid carcinoma.},
  author={Hassan M Heshmati and Hossein Gharib and Jon A. van Heerden and Glen W. Sizemore},
  journal={The American journal of medicine},
  year={1997},
  volume={103 1},
  pages={60-9}
}
Recent advances in the diagnosis and treatment of medullary thyroid carcinoma (MTC) have been significant, but some issues remain controversial. MTC may occur either as a hereditary or a nonhereditary entity. Hereditary MTC can occur either alone--familial MTC (FMTC)--or as the thyroid manifestation of multiple endocrine neoplasia type 2 (MEN 2) syndromes (MEN 2A and MEN 2B). These hereditary disorders are due to germline mutations in the RET proto-oncogene. Early diagnosis and treatment… CONTINUE READING