Advances and challenges in the use of nanoparticles to optimize PK/PD interactions of combined anti-cancer therapies.

@article{Liu2014AdvancesAC,
  title={Advances and challenges in the use of nanoparticles to optimize PK/PD interactions of combined anti-cancer therapies.},
  author={Yarong Liu and Jennifer A. Rohrs and Pin Wang},
  journal={Current drug metabolism},
  year={2014},
  volume={15 8},
  pages={818-28}
}
Combination chemotherapy has become the primary strategy for treating cancer; however, the clinical success of combination treatments is limited by the distinct pharmacokinetics (PK) of different drugs, which lead to nonuniform distribution and an inability to coordinate dosing regimes at the site of the tumor. In the first half of this review, we will… CONTINUE READING