Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics.

@article{Kaltashov2012AdvancesAC,
  title={Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics.},
  author={Igor A Kaltashov and Cedric E. Bobst and Rinat R Abzalimov and Guanbo Wang and Burcu Baykal and Shunhai Wang},
  journal={Biotechnology advances},
  year={2012},
  volume={30 1},
  pages={210-22}
}
Biopharmaceuticals are a unique class of medicines due to their extreme structural complexity. The structure of these therapeutic proteins is critically important for their efficacy and safety, and the ability to characterize it at various levels (from sequence to conformation) is critical not only at the quality control stage, but also throughout the discovery and design stages. Biological mass spectrometry (MS) offers a variety of approaches to study structure and behavior of complex protein… CONTINUE READING

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