Advances Pertaining to the Pharmacology and Interactions of Irreversible Nonselective Monoamine Oxidase Inhibitors

  title={Advances Pertaining to the Pharmacology and Interactions of Irreversible Nonselective Monoamine Oxidase Inhibitors},
  author={P. Gillman},
  journal={Journal of Clinical Psychopharmacology},
  • P. Gillman
  • Published 2011
  • Chemistry, Medicine
  • Journal of Clinical Psychopharmacology
  • Recent advances clarifying the pharmacology and interactions of irreversible nonselective monoamine oxidase inhibitors that have not been considered in depth lately are discussed. These new data elucidate aspects of enzyme inhibition and pharmacokinetic interactions involving amine oxidases, cytochrome P450 enzymes, aminotransferases (transaminases), and decarboxylases (carboxy-lyases) and the effects of tyramine. Phenelzine and tranylcypromine remain widely available, and many publications… CONTINUE READING
    44 Citations
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    • 63
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    Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations
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    Current Place of Monoamine Oxidase Inhibitors in the Treatment of Depression
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    Monoamine oxidase inhibitors and neuroprotection: a review.
    • 34
    Tranylcypromine in mind (Part I): Review of pharmacology
    • 18
    Selective inhibitors of monoamine oxidase type B and the "cheese effect".
    • 72
    "Much ado about nothing": monoamine oxidase inhibitors, drug interactions, and dietary tyramine.
    • 4
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    Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration
    • 30
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    Inhibitory Effects of the Monoamine Oxidase Inhibitor Tranylcypromine on the Cytochrome P450 Enzymes CYP2C19, CYP2C9, and CYP2D6
    • 29
    Tricyclic antidepressant pharmacology and therapeutic drug interactions updated
    • P. Gillman
    • Medicine, Chemistry
    • British journal of pharmacology
    • 2007
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    • PDF
    Inhibition of Cytochrome P450 (CYP450) Isoforms by Isoniazid: Potent Inhibition of CYP2C19 and CYP3A
    • 155
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    Monoamine oxidase inhibitors: a modern guide to an unrequited class of antidepressants.
    • 118
    • PDF
    On the binding of monoamine oxidase inhibitors to some sites distinct from the MAO active site, and effects thereby elicited.
    • 29
    Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes
    • 125