Corpus ID: 212560485

Advancement of polymer–based nanoparticles as smart drug delivery systems in neurodegenerative medicine

@inproceedings{Mansoor2019AdvancementOP,
  title={Advancement of polymer–based nanoparticles as smart drug delivery systems in neurodegenerative medicine},
  author={Keyanpour Rad Mansoor and K. Sima and Kianpour Rad Soheila},
  year={2019}
}
Neurodegenerative diseases (NDs), such as Alzheimer, Parkinson, amyotrophic lateral sclerosis (ALS), strokes, spinal cord injuries, glioblastoma, Huntington’s and others are caused by progressive dysfunction and death of neurons and are becoming increasingly prevalent and rising rapidly with advancement of age.1,2 Such brain disorders are usually caused by highly complex formation process of variety of cytotoxic protein aggregates with different structures and morphologies. The protein… Expand

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References

SHOWING 1-10 OF 56 REFERENCES
Advances in the treatment of neurodegenerative disorders employing nanoparticles.
TLDR
The aim of this review is to summarize the last patents, clinical trials and news related with nanoparticles technology for the treatment of neurodegenerative diseases. Expand
Nanotechnology for neurodegenerative disorders.
TLDR
This review focuses on the state-of-the-art of nanomaterials suitable for therapy and diagnostic imaging of the most common neurodegenerative disorders, as well as for neuroprotection and neuronal tissue regeneration. Expand
Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
TLDR
This review addresses the pathophysiology of the more common neurological disorders and novel drug candidates, along with targeted nanoparticle applications for brain delivery, and yields some promising results. Expand
Protein aggregation and neurodegenerative diseases: From theory to therapy.
TLDR
This review summarizes the existing information on the molecular mechanism of protein misfolding and aggregation involved in Neurodegeneration stressing on the possible therapeutic intervention in neurodegenerative diseases. Expand
Old Drugs as New Treatments for Neurodegenerative Diseases
TLDR
There is an urgent need for new treatments for this kind of disease, since the World Health Organization has predicted that neurodegenerative diseases affecting motor function will become the second-most prevalent cause of death in the next 20 years. Expand
Bio-inspired nano tools for neuroscience
TLDR
This review is an attempt to comprehend the progress in understanding the obstacles posed by the complex physiology of the nervous system and the innovations in design and fabrication of advanced nanomaterials drawing inspiration from natural phenomenon to provide an insight into the huge potential of nanotechnology platforms in neuroscience. Expand
Biodegradable polymeric nanostructures: design and advances in oral drug delivery for neurodegenerative disorders
Several strategies have been developed to increase the oral administration of hydrophobic drugs related to neurodegenerative diseases, namely, nanocarriers like polymeric nanoparticles, polymericExpand
Engineered nanoparticles. How brain friendly is this new guest?
TLDR
It is important to design adequate models and experimental systems to evaluate in a reliable and controlled fashion the effects of NPs on the brain, and generate data representative of effects on the human brain, thereby useful for developing robust and valid nanosafety standards. Expand
The blood–brain barrier in neurodegenerative disease: a rhetorical perspective
TLDR
This review discusses recent reports suggesting the involvement of peripheral factors including toxins and elements of adaptive immunity that may not only play a role in pathogenesis, but also progression of neurodegenerative diseases. Expand
Nanomedicines and stroke: Toward translational research
TLDR
This review aims to tackle some of the key challenges that have to be taken into account when developing and evaluating a new nanomedicines, with a special emphasis on the development of nanomediines for the treatment of stroke. Expand
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