Advancement in the modeling of pressure-flow for the guidance of development and scale-up of commercial-scale biopharmaceutical chromatography.

Abstract

This paper details the advancements made in the modeling of open column and packed bed pressure-flow. The theoretical description is a one-dimensional elasticity model. By accounting for the loss of intra-particle porosity through empiricism, and by systematically selecting the functional form of the elastic modulus from stress-strain data, this model can… (More)
DOI: 10.1016/j.chroma.2008.02.113

Topics

21 Figures and Tables

Slides referencing similar topics