Advancement in the modeling of pressure-flow for the guidance of development and scale-up of commercial-scale biopharmaceutical chromatography.


This paper details the advancements made in the modeling of open column and packed bed pressure-flow. The theoretical description is a one-dimensional elasticity model. By accounting for the loss of intra-particle porosity through empiricism, and by systematically selecting the functional form of the elastic modulus from stress-strain data, this model can… (More)
DOI: 10.1016/j.chroma.2008.02.113


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