Advancement in Protein Inference from Shotgun Proteomics Using Peptide Detectability

  title={Advancement in Protein Inference from Shotgun Proteomics Using Peptide Detectability},
  author={Pedro Alves and Randy J. Arnold and Milos V. Novotny and Predrag Radivojac and James P. Reilly and Haixu Tang},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
A major challenge in shotgun proteomics has been the assignment of identified peptides to the proteins from which they originate, referred to as the protein inference problem. Redundant and homologous protein sequences present a challenge in being correctly identified, as a set of peptides may in many cases represent multiple proteins. One simple solution to this problem is the assignment of the smallest number of proteins that explains the identified peptides. However, it is not certain that a… CONTINUE READING
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