Advanced protein glycosylation in diabetes and aging.

@article{Brownlee1995AdvancedPG,
  title={Advanced protein glycosylation in diabetes and aging.},
  author={Michael Brownlee},
  journal={Annual review of medicine},
  year={1995},
  volume={46},
  pages={223-34}
}
Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and… CONTINUE READING
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