Advanced polymeric matrix for valvular complications.

  title={Advanced polymeric matrix for valvular complications.},
  author={Gayathri Acharya and Richard A. Hopkins and Chi Ho Lee},
  journal={Journal of biomedical materials research. Part A},
  volume={100 5},
Poly(L-lactic acid) (PLLA) matrix systems incorporated with poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) containing nitric oxide (NO) donors (DETA NONOate) were developed for prevention of heart valve complications through sustained and controlled release of NO. PLLA matrices were prepared using the salt leaching method and the properties and drug release profiles were characterized. For assessment of the effects of PLLA systems on the pharmacological responses and cytotoxicity… CONTINUE READING