Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice.

@article{Foldi2010AdvancedPA,
  title={Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice.},
  author={Claire J. Foldi and Darryl Walter Eyles and J J Mcgrath and Thomas H J Burne},
  journal={The European journal of neuroscience},
  year={2010},
  volume={31 3},
  pages={556-64}
}
Advanced paternal age (APA) is associated with an increased risk of neurodevelopmental disorders such as autism and schizophrenia. A previous study in mice suggested that the offspring of aged sires have altered locomotion and avoidance learning. The aim of the current study was to conduct a comprehensive behavioural screen in adult offspring of mice of APA. We also examined brain morphology in neonate and adult mice. The adult offspring of 12- to 18-month-old (APA) and 4-month-old (control… CONTINUE READING
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