Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms

@inproceedings{Janecka2017AdvancedPA,
  title={Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms},
  author={Magdalena Janecka and Jonathan Mill and Marinelle Basson and Anne Goriely and Helen Spiers and Abraham Reichenberg and Leonard C. Schalkwyk and Cathy Fernandes},
  booktitle={Translational Psychiatry},
  year={2017}
}
Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both… CONTINUE READING
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