Advanced oxidation protein products induce vascular calcification by promoting osteoblastic trans-differentiation of smooth muscle cells via oxidative stress and ERK pathway.

@article{You2009AdvancedOP,
  title={Advanced oxidation protein products induce vascular calcification by promoting osteoblastic trans-differentiation of smooth muscle cells via oxidative stress and ERK pathway.},
  author={Huaizhou You and Haichun Yang and Qiuyu Zhu and Mingxin Li and Jun Xue and Yong Gu and Shanyan Lin and Feng Ding},
  journal={Renal failure},
  year={2009},
  volume={31 4},
  pages={313-9}
}
Vascular calcification is an actively regulated process similar to bone formation. Advanced oxidation protein products (AOPPs) have been demonstrated to be novel markers of oxidant-mediated protein damage. The present study investigated the role of AOPPs in inducing osteoblastic trans-differentiation and calcification of smooth muscle cells in vitro. We… CONTINUE READING