Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model.

@article{Li2007AdvancedOP,
  title={Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model.},
  author={Hong Li and Fan-fan Hou and Xun Zhang and Ping Yan Chen and Shang Xi Liu and Jian Xun Feng and Zhi Qiang Liu and Yue Xin Shan and Guo Bao Wang and Zhan Mei Zhou and Jian Wei Tian and D I Xie},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 2},
  pages={528-38}
}
Accumulation of plasma advanced oxidation protein products (AOPP) has been found in patients with chronic kidney disease. However, the biologic consequences of AOPP consumption on progression of renal disease still are unclear. For testing of the hypothesis that AOPP accelerate progression of chronic kidney disease, Sprague-Dawley rats were subjected to five-sixths nephrectomy (5/6 Nx) or to sham operation. Rats in each group were randomly assigned in three subgroups (n = 30 in each group) and… CONTINUE READING