Advanced ovarian cancer: phase III randomized study of sequential cisplatin-topotecan and carboplatin-paclitaxel vs carboplatin-paclitaxel.

@article{Hoskins2010AdvancedOC,
  title={Advanced ovarian cancer: phase III randomized study of sequential cisplatin-topotecan and carboplatin-paclitaxel vs carboplatin-paclitaxel.},
  author={Paul Hoskins and Ignace Vergote and Andr{\'e}s Cervantes and Dong Tu and Gavin Stuart and Piero Zola and Andrade Poveda and David Provencher and Dyonissios Katsaros and Bel{\'e}n Ojeda and Prafull Ghatage and Robert Grimshaw and Araceli Casado and L Elit and C{\'e}sar Mendiola and Akira Sugimoto and V D'hondt and Aabha Oza and Josep Ram{\'o}n Germ{\`a} and M Roy and Laura Brotto and Dawei Chen and Elizabeth A. Eisenhauer},
  journal={Journal of the National Cancer Institute},
  year={2010},
  volume={102 20},
  pages={1547-56}
}
BACKGROUND Topotecan has single-agent activity in recurrent ovarian cancer. It was evaluated in a novel combination compared with standard frontline therapy. METHODS Women aged 75 years or younger with newly diagnosed stage IIB or greater ovarian cancer, Eastern Cooperative Oncology Group Performance Status of 1 or less, were stratified by type of primary surgery and residual disease, treatment center, and age; then randomly assigned to one of the two 21-day intravenous regimens. Patients in… CONTINUE READING

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