Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors.

@article{NgreSalvayre2008AdvancedLP,
  title={Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors.},
  author={Anne N{\`e}gre-Salvayre and Christelle Coatrieux and C Ingueneau and Robert Salvayre},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 1},
  pages={6-20}
}
Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and Advanced Glycation end products (AGEs), accumulate with ageing and oxidative stress-related diseases, such as atherosclerosis, diabetes or neurodegenerative diseases. RCCs induce the 'carbonyl stress' characterized by the formation of adducts and cross-links on proteins, which progressively leads to impaired protein function and damages in all… CONTINUE READING
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