Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution.

@article{Sutherland2007AdvancedIO,
  title={Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution.},
  author={Vicki L Sutherland and Jerilyn A. Timlin and Linda T. Nieman and John F. Guzowski and Monica K Chawla and Paul F Worley and Badri Roysam and Bruce L. McNaughton and Michael B. Sinclair and Carol A. Barnes},
  journal={Journal of neuroscience methods},
  year={2007},
  volume={160 1},
  pages={144-8}
}
Simultaneous imaging of multiple cellular components is of tremendous importance in the study of complex biological systems, but the inability to use probes with similar emission spectra and the time consuming nature of collecting images on a confocal microscope are prohibitive. Hyperspectral imaging technology, originally developed for remote sensing applications, has been adapted to measure multiple genes in complex biological tissues. A spectral imaging microscope was used to acquire… CONTINUE READING

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