Advanced glycosylation end products stimulate the growth but inhibit the prostacyclin-producing ability of endothelial cells through interactions with their receptors.

@article{Yamagishi1996AdvancedGE,
  title={Advanced glycosylation end products stimulate the growth but inhibit the prostacyclin-producing ability of endothelial cells through interactions with their receptors.},
  author={Shin-ichiro Yamagishi and Yusuke Yamamoto and Shuko Harada and Chih Chao Hsu and Hiroshi Yamamoto},
  journal={FEBS letters},
  year={1996},
  volume={384 1},
  pages={103-6}
}
The influence of advanced glycosylation end products (AGE) on endothelial cells was investigated. When human umbilical endothelial cells were cultured with AGE-bovine serum albumin, viable cell number as well as DNA synthesis was significantly stimulated, whereas prostacyclin production by the endothelial cells was decreased. Antisense oligodeoxyribonucleotides against mRNA coding for AGE receptor were found to reverse both the AGE-induced growth stimulation and the inhibition of prostacyclin… CONTINUE READING