Advanced glycation in D-galactose induced mouse aging model.

  title={Advanced glycation in D-galactose induced mouse aging model.},
  author={Xiao-hong Song and Meihua Bao and Dan Li and Yanzhi Li},
  journal={Mechanisms of ageing and development},
  volume={108 3},
It was first reported in China that injection of a low dose of D-galactose into mice could induce changes which resembled accelerated aging. The aging model shows neurological impairment, decreased activity of anti-oxidant enzymes, and poor immune responses. However, the underlining mechanism remains largely unknown. D-galactose is a reducing sugar that can form advanced glycation endproducts (AGE) in vivo. To investigate the role of AGE in this aging model, a group of 5-month-old C57 mice were… CONTINUE READING
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