Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

@article{Srikanth2011AdvancedGE,
  title={Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease},
  author={V. Srikanth and Annette E. Maczurek and T. Phan and M. Steele and Bernadette Westcott and Damian Juskiw and G. M{\"u}nch},
  journal={Neurobiology of Aging},
  year={2011},
  volume={32},
  pages={763-777}
}
Alzheimer's disease (AD) is the most common dementing disorder of late life. Although there might be various different triggering events in the early stages of the disease, they seem to converge on a few characteristic final pathways in the late stages, characterized by inflammation and neurodegeneration. In this review, we revisit the hypothesis that advanced glycation endproducts (AGEs) and their receptor RAGE may play an important role in disease pathogenesis. Accumulation of AGEs in cells… Expand
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