Advanced glycation endproducts accelerate calcification in microvascular pericytes.

@article{Yamagishi1999AdvancedGE,
  title={Advanced glycation endproducts accelerate calcification in microvascular pericytes.},
  author={Shin-ichiro Yamagishi and Hiroaki Fujimori and Hideto Yonekura and Noriaki Tanaka and Hiroshi Yamamoto},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={258 2},
  pages={353-7}
}
Vascular calcification in advanced atherosclerosis is frequently associated with diabetes, and is a predictor of future cardiovascular events. To investigate the molecular mechanisms of vascular calcification, we examined whether advanced glycation endproducts (AGE) formed at an accelerated rate under diabetes induce the osteoblastic differentiation of pericytes, a mesenchymal progenitor. First, von Kossa staining demonstrated that AGE significantly increased the number of calcified nodules in… CONTINUE READING