Advanced glycation endproducts: A biomarker for age as an outcome predictor after cardiac surgery?

@article{Simm2007AdvancedGE,
  title={Advanced glycation endproducts: A biomarker for age as an outcome predictor after cardiac surgery?},
  author={A. Simm and J. Wagner and T. Gursinsky and N. Nass and I. Friedrich and R. Schinzel and E. Czeslik and R. Silber and R. Scheubel},
  journal={Experimental Gerontology},
  year={2007},
  volume={42},
  pages={668-675}
}
OBJECTIVE A decline in the function of all organs can be detected during ageing. Although the trend appears to be stable, deviation within the elderly population is much greater in comparison to young controls. The aim of the study was to identify a marker of senescence which correlates to heart function. Advanced glycation endproducts (AGEs) accumulate with age and are associated with degenerative diseases. METHODS Carboxymethyllysine (CML) concentrations in the pericardial fluid (as a… Expand
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TLDR
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The increase of skeletal muscle AGEs/RAGE and markers of inflammation and oxidative injury in association with weight gain and old age suggest a pathogenic role of A GEs in weight gainand in sarcopenia of aging. Expand
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