Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells.

@article{Yamagishi2003AdvancedGE,
  title={Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells.},
  author={Sho-ichi Yamagishi and Yosuke Inagaki and Tamami Okamoto and Shinjiro Amano and Kohachiro Koga and Masayoshi Takeuchi},
  journal={Kidney international},
  year={2003},
  volume={63 2},
  pages={464-73}
}
BACKGROUND We have shown previously that OPB-9195, a novel inhibitor of advanced glycation end products (AGE), significantly prevented renal tubular injury and tubulointerstitial fibrosis in spontaneous diabetic rats. However, the molecular mechanisms underlying this have not been fully elucidated. METHODS Three immunochemically distinct AGE were prepared by incubating bovine serum albumin (BSA) with glucose, glyceraldehyde, or methylglyoxal. Then, the effects of AGE on human proximal tubular… CONTINUE READING

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