Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation

@article{Shaikh2008AdvancedGE,
  title={Advanced glycation end products induce in vitro cross‐linking of $\alpha$‐synuclein and accelerate the process of intracellular inclusion body formation},
  author={S. Shaikh and Louise F B Nicholson},
  journal={Journal of Neuroscience Research},
  year={2008},
  volume={86}
}
Cross‐linking of α‐synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, α‐synuclein‐positive Lewy bodies in the brains of both PD as well as incidental Lewy body disease patients, suggesting a role for AGEs in α‐synuclein cross‐linking and Lewy body formation… Expand
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