Advanced glycation end products induce choroidal endothelial cell proliferation, matrix metalloproteinase-2 and VEGF upregulation in vitro

@article{Hoffmann2002AdvancedGE,
  title={Advanced glycation end products induce choroidal endothelial cell proliferation, matrix metalloproteinase-2 and VEGF upregulation in vitro},
  author={Stephan Hoffmann and Ulrike Friedrichs and Wolfram Eichler and Adam D. Rosenthal and Peter Wiedemann},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2002},
  volume={240},
  pages={996-1002}
}
Abstract Background. Advanced glycation end products (AGEs) are considered to be important modulators of angiogenesis and accumulate in choroidal neovascularization (CNV). Their effects regarding cells involved in proliferation of CNV [retinal pigment epithelial (RPE) cells, Müller cells and choroidal endothelial cells (CECs)] were investigated. Furthermore, the effects of AGEs on expression of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) by CECs were… CONTINUE READING

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