Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses.

@article{Basta2002AdvancedGE,
  title={Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses.},
  author={Giuseppina Basta and Guido Lazzerini and Marika Massaro and Tommaso Simoncini and Piero Tanganelli and Caifeng Fu and Thomas Kislinger and David M. Stern and Ann Marie Schmidt and Raffaele De Caterina},
  journal={Circulation},
  year={2002},
  volume={105 7},
  pages={816-22}
}
BACKGROUND The products of nonenzymatic glycation and oxidation of proteins, the advanced glycation end products (AGEs), form under diverse circumstances such as aging, diabetes, and kidney failure. Recent studies suggested that AGEs may form in inflamed foci, driven by oxidation or the myeloperoxidase pathway. A principal means by which AGEs alter cellular properties is through interaction with their signal-transduction receptor RAGE. We tested the hypothesis that interaction of AGEs with RAGE… CONTINUE READING
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