Advanced glycation end-products activate extracellular signal-regulated kinase via the oxidative stress-EGF receptor pathway in renal fibroblasts.

@article{Chen2010AdvancedGE,
  title={Advanced glycation end-products activate extracellular signal-regulated kinase via the oxidative stress-EGF receptor pathway in renal fibroblasts.},
  author={San-Cher Chen and J Y Guh and Chi-Ching Hwang and Shean-jaw Chiou and Tai-Du Lin and Yu-Ming Ko and Jau-Shyang Huang and Yulin Yang and Lea-Yea Chuang},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={109 1},
  pages={38-48}
}
Advanced glycation end-products (AGEs), epidermal growth factor receptor (EGFR), reactive oxygen species (ROS), and extracellular signal-regulated kinases (ERK) are implicated in diabetic nephropathy (DN). Therefore, we asked if AGEs-induced ERK protein phosphorylation and mitogenesis are dependent on the receptor for AGEs (RAGE)-ROS-EGFR pathway in normal rat kidney interstitial fibroblast (NRK-49F) cells. We found that AGEs (100 microg/ml) activated EGFR and ERK1/2, which was attenuated by… CONTINUE READING
8 Citations
50 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…