Advanced glycation end‐products induce calpain‐mediated degradation of ezrin

@article{McRobert2012AdvancedGE,
  title={Advanced glycation end‐products induce calpain‐mediated degradation of ezrin},
  author={E. A. McRobert and A. Young and L. Bach},
  journal={The FEBS Journal},
  year={2012},
  volume={279}
}
Advanced glycation end‐products (AGEs) are important mediators of diabetic complications via incompletely understood pathways. AGEs bind to intracellular ERM proteins (ezrin, radixin and moesin) that modulate cell shape, motility, adhesion and signal transduction. AGEs bind to the N‐terminal domain of ezrin but not full‐length ezrin. The AGE binding site may be made accessible either by proteolysis releasing an N‐terminal fragment or ezrin activation by phosphorylation. Increased intracellular… Expand
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