Advanced first trimester screening (AFS): an improved test strategy for the individual risk assessment of fetal aneuploidies and malformations

@article{Schmidt2007AdvancedFT,
  title={Advanced first trimester screening (AFS): an improved test strategy for the individual risk assessment of fetal aneuploidies and malformations},
  author={Peter Schmidt and Joachim Rom and Holger Maul and Bernhard Vaske and Peter Hillemanns and Alexander Scharf},
  journal={Archives of Gynecology and Obstetrics},
  year={2007},
  volume={276},
  pages={159-166}
}
First trimester risk assessment for fetal aneuploidies is computed on the base of a general background risk, which is depending on the maternal age. Thereby, the adjusted risk tends to rise with increasing age. Obversely, more unsuspicious fetal parameters [measurement of the nuchal translucency (NT) and biochemical parameters, free beta human chorionic gonadotropine (fß-Hcg) and pregnancy associated plasma protein A (Papp-A)] have to be observed to result in an unsuspicious test at higher age… CONTINUE READING