Advanced fabrication approaches to controlled delivery systems for epilepsy treatment

@article{vanTienderen2018AdvancedFA,
  title={Advanced fabrication approaches to controlled delivery systems for epilepsy treatment},
  author={Gilles Sebastiaan van Tienderen and Marius Berthel and Zhilian Yue and Mark J. Cook and Xiao Liu and Stephen Beirne and Gordon G. Wallace},
  journal={Expert Opinion on Drug Delivery},
  year={2018},
  volume={15},
  pages={915 - 925}
}
ABSTRACT Introduction: Epilepsy is a chronic brain disease characterized by unprovoked seizures, which can have severe consequences including loss of awareness and death. Currently, 30% of epileptic patients do not receive adequate seizure alleviation from oral routes of medication. Over the last decade, local drug delivery to the focal area of the brain where the seizure originates has emerged as a potential alternative and may be achieved through the fabrication of drug-loaded polymeric… 
View on Taylor & Francis
ro.uow.edu.au
12 Citations
Background Citations
4

12 Citations

Bypassing the Blood–Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies
TLDR
Although an invasive procedure, bypassing the BBB by targeted intracranial drug delivery is an attractive approach to circumvent BBB-associated drug resistance mechanisms and to lower the risk of systemic and neurologic adverse effects.
Recent advances on drug delivery nanocarriers for cerebral disorders
TLDR
Different types of brain drug delivery nanocarriers are classified and summarized, especially their significant achievements, to present several recommendations and directions for future strategies of cerebral delivery.
Microdevices to successfully deliver orally administered drugs
Gelatin Methacryloyl Hydrogels for Musculoskeletal Tissue Regeneration
TLDR
This review highlights recent advances of GelMA hydrogels in the emerging fields of musculoskeletal drug delivery, involving therapeutic drugs, delivery approaches, and material design involving organic or inorganic materials, 3D printing.
Biodegradable Polymers for Biomedical Additive Manufacturing
3D bioprinting: current status and trends—a guide to the literature and industrial practice
The multidisciplinary research field of bioprinting combines additive manufacturing, biology and material sciences to create bioconstructs with three-dimensional architectures mimicking natural…
Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?
TLDR
A better understanding of the complex alterations in BBB structure and function following seizures and in epilepsy may lead to novel therapeutic interventions allowing the prevention and treatment of epilepsy as well as other detrimental neuro-psychiatric sequelae of brain injury.
Controlled Release of Naringin in GelMA-Incorporated Rutile Nanorod Films to Regulate Osteogenic Differentiation of Mesenchymal Stem Cells
TLDR
It is demonstrated that the release behavior of naringin on rutile nanorod films could be controlled by either mixing naring in with gelatin methacryloyl (GelMA) before spinning onto the films or soaking the obtained GelMA-incorporated films with the naringIn solution to achieve the distinct degradation- type release and diffusion-type release, respectively.
In-process thermal treatment of polylactic acid in fused deposition modelling
ABSTRACT Polylactic acid (PLA) is one of the most widely used open source fused filament fabrication materials due to its ease of extrusion, biodegradability, and mechanical strength. The mechanical…
Rat Calvarial Bone Regeneration by 3D-Printed Beta-Tricalcium Phosphate Incorporating MicroRNA-200c
TLDR
The results strongly indicate that through use of SEPS 3D-printing technology, hybrid scaffolds combined by osteoconductive biomaterials and osteoinductive biologics can be used as superior bone substitutes for the clinical treatment of large bone defects.
...
...

References

SHOWING 1-10 OF 97 REFERENCES
A simple and versatile method for microencapsulation of anti-epileptic drugs for focal therapy of epilepsy.
TLDR
In order to develop effective local delivery systems for anti-epilepsy drug (AED), a variety of core-shell microcapsules via electrojetting are prepared, where a more hydrophobic polymer shell acts as a physical barrier to control the rate of drug release from the drug-loaded polymeric core.
Novel methods of antiepileptic drug delivery -- polymer-based implants.
Development of drug-loaded polymer microcapsules for treatment of epilepsy.
TLDR
Development of fibre- and sphere-based microcapsules that exhibit controllable uniform morphologies and drug release profiles as predicted by mathematical modelling are reported, indicating clinical compliance for neural implantation and therapeutic drug delivery.
Polymer-based drug delivery devices for neurological disorders.
TLDR
The current status of animal and human studies in polymer based therapies is reviewed, addressing some of the practical obstacles and examining the range of potential applications in chronic neurological disease.
Nanotechnology for delivery of drugs to the brain for epilepsy
Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats.
TLDR
It is shown that small injections of drug-loaded microspheres are biologically tolerated and released PHT can control seizures for the expected period of time that is in accord with in-vitro release data.
Potential New Methods for Antiepileptic Drug Delivery
TLDR
In the near future, it is likely that cell transplants that generate neurotransmitters and neuromodulators will accomplish renewable endogenous drug delivery and new delivery systems should significantly improve the therapeutic/toxic ratio of AEDs.
A 3D-printed local drug delivery patch for pancreatic cancer growth suppression.
  • H. Yi, Yeong-Jin Choi, D. Cho
  • Biology, Materials Science
    Journal of controlled release : official journal of the Controlled Release Society
  • 2016
Advances in drug delivery via electrospun and electrosprayed nanomaterials
TLDR
This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.
The intracerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats
...
...