Advanced fabrication approaches to controlled delivery systems for epilepsy treatment

@article{vanTienderen2018AdvancedFA,
  title={Advanced fabrication approaches to controlled delivery systems for epilepsy treatment},
  author={Gilles Sebastiaan van Tienderen and Marius Berthel and Zhilian Yue and Mark J. Cook and Xiao Liu and Stephen Beirne and Gordon G. Wallace},
  journal={Expert Opinion on Drug Delivery},
  year={2018},
  volume={15},
  pages={915 - 925}
}
ABSTRACT Introduction: Epilepsy is a chronic brain disease characterized by unprovoked seizures, which can have severe consequences including loss of awareness and death. Currently, 30% of epileptic patients do not receive adequate seizure alleviation from oral routes of medication. Over the last decade, local drug delivery to the focal area of the brain where the seizure originates has emerged as a potential alternative and may be achieved through the fabrication of drug-loaded polymeric… 
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References

SHOWING 1-10 OF 97 REFERENCES
A simple and versatile method for microencapsulation of anti-epileptic drugs for focal therapy of epilepsy.
TLDR
In order to develop effective local delivery systems for anti-epilepsy drug (AED), a variety of core-shell microcapsules via electrojetting are prepared, where a more hydrophobic polymer shell acts as a physical barrier to control the rate of drug release from the drug-loaded polymeric core.
Development of drug-loaded polymer microcapsules for treatment of epilepsy.
TLDR
Development of fibre- and sphere-based microcapsules that exhibit controllable uniform morphologies and drug release profiles as predicted by mathematical modelling are reported, indicating clinical compliance for neural implantation and therapeutic drug delivery.
Polymer-based drug delivery devices for neurological disorders.
TLDR
The current status of animal and human studies in polymer based therapies is reviewed, addressing some of the practical obstacles and examining the range of potential applications in chronic neurological disease.
Nanotechnology for delivery of drugs to the brain for epilepsy
Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats.
TLDR
It is shown that small injections of drug-loaded microspheres are biologically tolerated and released PHT can control seizures for the expected period of time that is in accord with in-vitro release data.
Potential New Methods for Antiepileptic Drug Delivery
TLDR
In the near future, it is likely that cell transplants that generate neurotransmitters and neuromodulators will accomplish renewable endogenous drug delivery and new delivery systems should significantly improve the therapeutic/toxic ratio of AEDs.
A 3D-printed local drug delivery patch for pancreatic cancer growth suppression.
  • H. Yi, Yeong-Jin Choi, D. Cho
  • Biology, Materials Science
    Journal of controlled release : official journal of the Controlled Release Society
  • 2016
Advances in drug delivery via electrospun and electrosprayed nanomaterials
TLDR
This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.
...
...