Advanced computational modeling for in vitro nanomaterial dosimetry

  title={Advanced computational modeling for in vitro nanomaterial dosimetry},
  author={Glen M DeLoid and Joel M. Cohen and Georgios Pyrgiotakis and Sandra Vanessa Pirela and Anoop K. Pal and Jiying Liu and Jelena Srebric and Philip Demokritou},
  journal={Particle and Fibre Toxicology},
Accurate and meaningful dose metrics are a basic requirement for in vitro screening to assess potential health risks of engineered nanomaterials (ENMs). Correctly and consistently quantifying what cells “see,” during an in vitro exposure requires standardized preparation of stable ENM suspensions, accurate characterizatoin of agglomerate sizes and effective densities, and predictive modeling of mass transport. Earlier transport models provided a marked improvement over administered… CONTINUE READING
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