Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns

@article{Habes2016AdvancedBA,
  title={Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns},
  author={Mohamad Habes and Deborah Janowitz and G Erus and Jon B. Toledo and Susan M. Resnick and Jimit Doshi and Sandra Van der Auwera and Katharina Wittfeld and Katrin Hegenscheid and Norbert Hosten and Reiner Biffar and Georg Homuth and Henry V{\"o}lzke and Hans J{\"o}rgen Grabe and Wolfgang Hoffmann and Christos Davatzikos},
  journal={Translational Psychiatry},
  year={2016},
  volume={6},
  pages={e775-}
}
We systematically compared structural imaging patterns of advanced brain aging (ABA) in the general-population, herein defined as significant deviation from typical BA to those found in Alzheimer disease (AD). The hypothesis that ABA would show different patterns of structural change compared with those found in AD was tested via advanced pattern analysis methods. In particular, magnetic resonance images of 2705 participants from the Study of Health in Pomerania (aged 20–90 years) were analyzed… CONTINUE READING
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Alzheimer’s disease: a protective factor for the ageing brain

Tsai L-H, R Madabhushi
Nature • 2014

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