Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base

Abstract

Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid (vinyl-ACCA) is in extremely high demand due to the pharmaceutical importance of this tailor-made, sterically constrained α-amino acid. Here we report the development of an advanced procedure for preparation of the target amino acid via two-step SN2 and SN2′ alkylation of novel… (More)
DOI: 10.1007/s00726-015-2138-3

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@article{Kawashima2015AdvancedAS, title={Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base}, author={Aki Kawashima and Shuangjie Shu and Ryosuke Takeda and Akie Kawamura and Tatsunori Sato and Hiroki Moriwaki and Jiang Wang and Kunisuke Izawa and Jos{\'e} Luis Ace{\~n}a and Vadim A Soloshonok and Hong Liu}, journal={Amino Acids}, year={2015}, volume={48}, pages={973-986} }