Advanced antisense therapies for postexposure protection against lethal filovirus infections

@article{Warren2010AdvancedAT,
  title={Advanced antisense therapies for postexposure protection against lethal filovirus infections},
  author={Travis K Warren and Kelly L. Warfield and Jay B. Wells and Dana L. Swenson and Kelly S Donner and Sean A. Van Tongeren and Nicole L Garza and Lian Cheng Dong and Dan V. Mourich and Stacy Crumley and Donald K. Nichols and Patrick L. Iversen and Sina Bavari},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={991-994}
}
Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various dosing strategies initiated 30–60 min after infection, protects >60% of rhesus monkeys against lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus… 
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