Advanced Technologies for Oral Controlled Release: Cyclodextrins for Oral Controlled Release

  title={Advanced Technologies for Oral Controlled Release: Cyclodextrins for Oral Controlled Release},
  author={Paulo Jos{\'e} Sal{\'u}stio and Patr{\'i}cia Proc{\'o}pio Pontes and Cla{\'u}dia Conduto and In{\^e}s Sanches and Catarina Carvalho and Jo{\~a}o Arrais and Helena M. Cabral Marques},
  journal={AAPS PharmSciTech},
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability, and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent gastrointestinal side effects and unpleasant smell or taste, to prevent drug–drug or drug–additive interactions, or even to convert oil and liquid drugs into microcrystalline or… CONTINUE READING

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