Advanced Methylome Analysis after Bisulfite Deep Sequencing: An Example in Arabidopsis

@inproceedings{Dinh2012AdvancedMA,
  title={Advanced Methylome Analysis after Bisulfite Deep Sequencing: An Example in Arabidopsis},
  author={Huy Q. Dinh and Manu Dubin and Fritz J Sedlazeck and Nicole Lettner and Ortrun Mittelsten Scheid and Arndt von Haeseler},
  booktitle={PloS one},
  year={2012}
}
Deep sequencing after bisulfite conversion (BS-Seq) is the method of choice to generate whole genome maps of cytosine methylation at single base-pair resolution. Its application to genomic DNA of Arabidopsis flower bud tissue resulted in the first complete methylome, determining a methylation rate of 6.7% in this tissue. BS-Seq reads were mapped onto an in silico converted reference genome, applying the so-called 3-letter genome method. Here, we present BiSS (Bisufite Sequencing Scorer), a new… CONTINUE READING

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