Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

  title={Advanced Maillard reaction end products are associated with Alzheimer disease pathology.},
  author={Mark A. Smith and S Taneda and Peggy L. Richey and Sachiko Miyata and Shirley ShiDu Yan and David Stern and Lawrence M. Sayre and Vincent M. Monnier and George Perry},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 12},
During aging long-lived proteins accumulate specific post-translational modifications. One family of modifications, termed Maillard reaction products, are initiated by the condensation between amino groups of proteins and reducing sugars. Protein modification by the Maillard reaction is associated with crosslink formation, decreased protein solubility, and increased protease resistance. Here, we present evidence that the characteristic pathological structures associated with Alzheimer disease… CONTINUE READING
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