Advanced Glycation in Health and Disease: Role of the Modern Environment

@article{Vlassara2005AdvancedGI,
  title={Advanced Glycation in Health and Disease: Role of the Modern Environment},
  author={H. Vlassara},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1043}
}
  • H. Vlassara
  • Published 2005
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: It is believed that intracellular and extracellular advanced glycation (AGEs) or lipoxidation end products (ALEs), together with dysregulated glucose and lipid metabolism, are important contributors to oxidant or carbonyl stress, enhanced cellular redox‐sensitive transcription factor activity, and impaired innate immune defense, causing over time inappropriate inflammatory responses. However, neither the magnitude nor the persistent nature of this increased prooxidant state are… Expand
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