Advanced BMP gene therapies for temporal and spatial control of bone regeneration.

@article{Wilson2013AdvancedBG,
  title={Advanced BMP gene therapies for temporal and spatial control of bone regeneration.},
  author={C. G. Wilson and Francisco M Mart{\'i}n-Saavedra and Nuria Vilaboa and Renny T. Franceschi},
  journal={Journal of dental research},
  year={2013},
  volume={92 5},
  pages={409-17}
}
Spatial and temporal patterns of bone morphogenetic protein (BMP) signaling are crucial to the assembly of appropriately positioned and shaped bones of the face and head. This review advances the hypothesis that reconstitution of such patterns with cutting-edge gene therapies will transform the clinical management of craniofacial bone defects attributed to trauma, disease, or surgical resection. Gradients in BMP signaling within developing limbs and orofacial primordia regulate proliferation… CONTINUE READING