Adults with late diagnosed PKU and severe challenging behaviour: a randomised placebo-controlled trial of a phenylalanine-restricted diet.

@article{Lee2009AdultsWL,
  title={Adults with late diagnosed PKU and severe challenging behaviour: a randomised placebo-controlled trial of a phenylalanine-restricted diet.},
  author={Phillip Lee and Allayne Amos and Linda Seay Robertson and Barbara E Fitzgerald and Ryan Hoskin and Maggie F Lilburn and Eleanor Weetch and Gavin J Murphy},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2009},
  volume={80 6},
  pages={
          631-5
        }
}
BACKGROUND Although early diagnosis and treatment in phenylketonuria (PKU) leads to excellent outcomes, a population of adults born before the introduction of newborn screening exists. They can have severe intellectual disabilities and behavioural problems, and are often dependent on full-time carers. Anecdotal evidence suggests that a diet that lowers blood phenylalanine concentration can have significant benefits upon behaviour. METHODS A prospective double-blind randomised placebo… CONTINUE READING
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