Adult pilocytic astrocytomas: clinical features and molecular analysis.

@article{Theeler2014AdultPA,
  title={Adult pilocytic astrocytomas: clinical features and molecular analysis.},
  author={Brett James Theeler and Benjamin Ellezam and Zsila S Sadighi and Vidya P Mehta and Minh-Ha Tran and Adekunle Michael Adesina and Janet M. Bruner and Vinay K. Puduvalli},
  journal={Neuro-oncology},
  year={2014},
  volume={16 6},
  pages={
          841-7
        }
}
BACKGROUND Adult pilocytic astrocytomas (PAs) are rare and have an aggressive clinical course compared with pediatric patients. Constitutive Ras/RAF/MAPK signaling appears to be an important oncogenic event in sporadic PA. We evaluated clinical data and molecular profiles of adult PAs at our institution. METHODS We identified 127 adult PAs in our institutional database. Cases with available tissue were tested for BRAF-KIAA1549 fusion/duplication (B-K fusion) by fluorescence in situ… CONTINUE READING
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