Adult patients with de novo acute myeloid leukemia and t(9; 11)(p22; q23) have a superior outcome to patients with other translocations involving band 11q23: a cancer and leukemia group B study.

@article{Mrzek1997AdultPW,
  title={Adult patients with de novo acute myeloid leukemia and t(9; 11)(p22; q23) have a superior outcome to patients with other translocations involving band 11q23: a cancer and leukemia group B study.},
  author={Krzysztof Mr{\'o}zek and Kristiina Heinonen and Daniel R. Lawrence and A J Carroll and Prasad R. K. Koduru and Kathleen W. Rao and Matthew P Strout and Robert E Hutchison and Joseph O. Moore and Robert J. Mayer and Charles A Schiffer and Clara D. Bloomfield},
  journal={Blood},
  year={1997},
  volume={90 11},
  pages={4532-8}
}
Following reports of childhood acute myeloid leukemia (AML) showing that patients with t(9; 11)(p22; q23) have a better prognosis than those with translocations between 11q23 and other chromosomes, we compared response to therapy and survival of 24 adult de novo AML patients with t(9; 11) with those of 23 patients with other 11q23 translocations [t(11q23)]. Apart from a higher proportion of French-American-British (FAB) M5 subtype in the t(9; 11) group (83% v 43%, P = .006), the patients with t… CONTINUE READING
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