Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling.

@article{Blaine2010AdultPA,
  title={Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling.},
  author={Stacy A. Blaine and Kevin C. Ray and Reginald Anunobi and Maureen A Gannon and M. Kay Washington and Anna L. Means},
  journal={Development},
  year={2010},
  volume={137 14},
  pages={
          2289-96
        }
}
Studies in both humans and rodents have found that insulin(+) cells appear within or near ducts of the adult pancreas, particularly following damage or disease, suggesting that these insulin(+) cells arise de novo from ductal epithelium. We have found that insulin(+) cells are continuous with duct cells in the epithelium that makes up the hyperplastic ducts of both chronic pancreatitis and pancreatic cancer in humans. Therefore, we tested the hypothesis that both hyperplastic ductal cells and… CONTINUE READING

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