Adult onset hemophagocytic lymphohistiocytosis prognosis is affected by underlying disease and coexisting viral infection: analysis of a single institution series of 35 patients.

@article{Cattaneo2017AdultOH,
  title={Adult onset hemophagocytic lymphohistiocytosis prognosis is affected by underlying disease and coexisting viral infection: analysis of a single institution series of 35 patients.},
  author={C Cattaneo and Margherita Oberti and Cristina Skert and Angela Passi and Mirko Farina and Alessandro Re and Paola Tozzi and Erika Borlenghi and Giuseppe Rossi},
  journal={Hematological oncology},
  year={2017},
  volume={35 4},
  pages={828-834}
}
Adult onset hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which can develop as a complication of many disorders. Early diagnosis is essential in order to avoid a fatal outcome. To confirm the diagnosis of acquired HLH made in a single institution series of adult patients with HLH-04 criteria, we applied the HScore and evaluated prognostic factors associated with clinical outcome. The median age of 35 patients was 54 (range 17-81), M/F ratio was 20/15. In 26/35 (74.3… CONTINUE READING
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