Adult-onset Still's disease.

  title={Adult-onset Still's disease.},
  author={M. Gerfaud-valentin and Yvan Jamilloux and Jean Iwaz and Pascal S{\`e}ve},
  journal={Autoimmunity reviews},
  volume={13 7},
First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. Macrophage and neutrophil activation is a hallmark of AOSD which can lead to a reactive hemophagocytic lymphohistiocytosis. As in the latter disease, the cytotoxic function of natural killer cells is decreased in… CONTINUE READING
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