Adult multicenter trials using dexrazoxane to protect against cardiac toxicity.

@article{Swain1998AdultMT,
  title={Adult multicenter trials using dexrazoxane to protect against cardiac toxicity.},
  author={Sandra M Swain},
  journal={Seminars in oncology},
  year={1998},
  volume={25 4 Suppl 10},
  pages={43-7}
}
Two large multicenter placebo controlled trials (088001 and 088006) in metastatic breast cancer found a significant cardioprotective effect of dexrazoxane when administered with doxorubicin. A delayed dose analysis found a protective effect even after a cumulative dose of doxorubicin of 300 mg/m2. Exploratory analysis combing the arms on the two studies found a cardioprotective effect of dexrazoxane either initially or after 300 mg/m2 when administered in patients older than 65 years, compared… CONTINUE READING

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