Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons.

@article{Hojo2004AdultMR,
  title={Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons.},
  author={Yasushi Hojo and Taka-aki Hattori and T. Enami and Aizo Furukawa and Kumiko Suzuki and Hiro-taka Ishii and Hideo Mukai and John Morrison and William G. M. Janssen and Shiro A J Kominami and Nobuhiro Harada and Tetsuya Kimoto and S Kawato},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 3},
  pages={865-70}
}
In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect dehydroepiandrosterone synthase, P45017alpha. In adult male rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017alpha and P450 aromatase, in pyramidal neurons in the CA1-CA3 regions, as well as in the granule cells in the dentate gyrus, by means of immunohistochemical staining of slices. Only a weak… CONTINUE READING
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