Adult interleukin-6 knockout mice show compromised neurogenesis.

  title={Adult interleukin-6 knockout mice show compromised neurogenesis.},
  author={Kellie K. Bowen and Robert J Dempsey and Raghu Vemuganti},
  volume={22 3},
Interleukin-6 (IL-6) is a proinflammatory cytokine known to modulate neurogenesis. We presently evaluated neural progenitor proliferation, survival, and phenotypic maturation in the hippocampal dentate gyrus, subventricular zone, and the posterior periventricle in the brains of IL-6 knockout mice and their wild-type littermates. In all the three neurogenic regions of the IL-6 mice there was a significant decrease in the number of 5-bromo-2-deoxyuridine positive (BrdU) proliferating progenitors… CONTINUE READING

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