Adult human buccal epithelial stem cells: identification, ex-vivo expansion, and transplantation for corneal surface reconstruction

@article{Priya2011AdultHB,
  title={Adult human buccal epithelial stem cells: identification, ex-vivo expansion, and transplantation for corneal surface reconstruction},
  author={Chidambaranathan Gowri Priya and Parthasarathy Arpitha and Shinde Vaishali and Namperumalsamy Venkatesh Prajna and Krishna Usha and Karande Sheetal and Veerappan Muthukkaruppan},
  journal={Eye},
  year={2011},
  volume={25},
  pages={1641-1649}
}
PurposeTo identify adult human buccal epithelial stem cells (SCs) on the basis of two parameters (high p63 expression and greater nucleus/cytoplasmic (N/C) ratio) and to evaluate clinical efficacy of ex-vivoexpanded autologous epithelium in bilateral limbal SC-deficient (LSCD) patients.MethodsThe epithelial cells were isolated from buccal biopsy and cultured on human amnion in culture inserts with 3T3 feeder layer. The SCs were identified on the basis of two-parameter analysis using confocal… CONTINUE READING
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